![]() “As the proportion of dogs with c-kit mutations was not different between treatment groups, c-kit mutation status did not predict treatment response as we had hoped. ![]() “Neither the progression free survival time (length of time during and after treatment that a patient lives without getting worse) nor overall survival time (length of time from the start of treatment that a patient is still alive) was significantly different between the treatment groups,” says Dr. “Our hypothesis was that MCT with c-kit mutations would have a superior response to toceranib compared to vinblastine,” Dr. Thamm and his team compared the effectiveness of toceranib (TOC), a KIT inhibitor sold as Palladia™, and vinblastine (VBL), a chemotherapy drug, in treating dogs with MCT with and without c-kit gene mutations. The study was published in 2018 in the Journal of Veterinary Internal Medicine. A protein found on the surface of many different types of cells, the KIT protein also may be found in higher than normal amounts or in a changed form on some types of cancer cells, including MCT. A study of checkpoint molecules, also supported by the American Boxer Charitable Foundation, is progressing this novel cancer immunotherapy in dogs.ĭouglas Thamm, VMD, DACVIM (Oncology), the Barbara Cox Anthony Professor of Oncology, led a multi-center study exploring the potential sensitivity of mast cell tumors with c-kit gene mutations to KIT-inhibiting drugs. A personalized medicine approach to MCTs that are more aggressive because they have a mutation in the c-kit gene looked at whether treatment with KIT inhibitors yielded treatment success. Investigations into innovative treatments for MCT include two studies funded by the AKC Canine Health Foundation. Kit Inhibiting Drugs & Checkpoint Inhibitors When these cells replicate out of control, they form an aggressive cancer. Mast cells are an important part of the immune system. The most common skin cancer in dogs, mast cell tumor is a cancer of a type of white blood cell found throughout the body. The prognosis for an individual dog with MCT depends on factors such as tumor grade, tumor stage and whether surgery is possible to completely remove the tumor. Except for one: Four have died of mast cell tumors (MCT).įor unknown reasons, Boxers have an increased risk for MCT, though any breed of dog or mixed breed can develop the cancer. ![]() Her entire life she has had Boxers and counts herself lucky that her dogs have had few of the health concerns common in the breed. “ 9 Dog Breeds With The Highest Cancer Rate” Accessed Jon Web MD.Growing up in a family with a pet Boxer, Joyce Baker Brown fell in love with the breed. Our team members are ready to help answer your questions. Oncology for dogs is available! If your pet has been diagnosed with cancer, contact our Pet Advocates at (833) PET-HERO or your local PetCure Oncology center.
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